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国家中医药管理局瘿病证治重点研究室

信息来源:院办 发布时间:2017-12-11

研究室简介:

    国家中医药管理局瘿病证治重点研究室致力于中医药与代谢性疾病的研究,研究内容包含:含碘中药对甲状腺疾病的治疗研究、甲状腺肿瘤的发病机制研究、糖尿病的自然疗法、胎儿起源的成人疾病研究等。

研究方向:

    研究方向一:含碘中药对甲状腺疾病的研究

    利用ICP-MS法测定中药碘含量明确治疗瘿病常见中药的碘含量,并运用含碘中药治疗甲亢,了解含碘中药对常见甲状腺疾病的影响

    研究方向二:甲状腺肿瘤的研究

    研究团队致力于甲状腺肿瘤的研究,包括甲状腺肿瘤的发病机制研究、甲状腺肿瘤耐药的研究以及甲状腺肿瘤的治疗研究,以甲状腺肿瘤干细胞为切入点,深入探讨甲状腺肿瘤的发病及耐药机制,同时研究中医药在甲状腺肿瘤治疗方面的潜力。

    研究方向三糖尿病的自然疗法

    研究利用限食、运动等手段逆转糖尿病的方法,我们前期已经发现短期限食降低2型糖尿病患者体重、血糖和血脂水平,增加胰岛素一相分泌能力,提示限食可以逆转糖尿病进程

    研究方向四:胎儿起源的成人疾病研究

    胚胎时期不良的宫内环境会导致胎儿物质代谢、组织结构和器官功能的改变,导致成年后罹患代谢性疾病的风险升高,我们研究母体肥胖对子代肥胖、2型糖尿病和高血压的影响及机制。


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 Fig.1 TSH and insulin.IGF-1 axis in nodule formation

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      Fig.2 The mechanism of calorie restriction of treating Type 2 diabetes


    近期发表的代表性论文:

1.Fan Y, Di H, Chen G, Mao X, Liu C. Effects of low carbohydrate diets in individuals with type 2 diabetes: systematic review and meta-analysis. Int J Clin Exp Med, 2016, 9(6):11166-11174.

2.Zheng R, Cao L, Cao W, Chu X, Hu Y, Zhang H, Xu J, Sun H, Bao W, Liu K, Liu C. Risk Factors for Hypogonadism in Male Patients with Type 2 Diabetes. J Diabetes Res. 2016, 2016(1):1-8.

3.Chen G, Nicula D, Renko K, Derwahl M. Synergistic anti-proliferative effect of metformin and sorafenib on growth of anaplastic thyroid cancer cells and their stem cells. Oncol Rep, 2015, 33(4):1994-2000.

4.Liu K, Mao X, Shi J, Lu Y, Liu C. Evaluation of lead and essential elements in whole blood during pregnancy: a cross-sectional study. Irish J Med Sci, 2016, 185(3):677-682.

5.Liu C, Li C, Chen J, Liu Y, Cheng Q, Xiang X, Chen G. Effects of a very low-calorie diet on insulin sensitivity and insulin secretion in overweight/obese and lean type 2 diabetes patients. Diabetes Metab. 2015, 41(6):513-515.

6.Wang K, Li L, Wu Y, Yang Y, Chen J, Zhang D, Liu Z, Xu J, Cao M, Mao X, Liu C. Increased serum gamma-glutamyltransferase levels are associated with ventricular instability in type 2 diabetes. Endocrine, 2016, 52(1):63-72.

7.Xu SH, Li XJ, Chen GF, Zheng QX, Yang Y, Hu YX, Wang K, Liu C. A questionnaire survey on the management of Graves' orbitopathy in China:A comparison with Europe and Latin-America. Chronic Diseases & Translational Medicine. 2015,1(2):117-122.

8.Zheng R, Liu K, Chen K, Cao W, Cao L, Zhang H, Sun H, Liu C. Lithium Carbonate in the Treatment of Graves' Disease with ATD-Induced Hepatic Injury or Leukopenia. Int J Endocrinol. 2015, 2015(6):1-7.

9.Wang K, Yang Y, Wu Y, Chen J, Zhang D, Liu C. The association of menstrual and reproductive factors with thyroid nodules in Chinese women older than 40 years of age. Endocrine, 2015, 48(2):603-614.

10.Wang K, Wu Y, Yang Y, Chen J, Zhang D, Hu Y, Liu Z, Xu J, Shen Q, Zhang N, Mao X, Liu C. The associations of bedtime, nocturnal, and daytime sleep duration with bone mineral density in pre- and post-menopausal women. Endocrine, 2015, 49(2):538-548.

11.Wang K, Yang Y, Wu Y, Chen J, Zhang D, Mao X, Wu X, Long X, Liu C. The association between insulin resistance and vascularization of thyroid nodules. J Clin Endocrinol Metab, 2015, 100(1):184-192.

12.Wang K, Yang Y, Wu Y, Chen J, Zhang D, Liu C. The association of menstrual and reproductive factors with thyroid nodules in Chinese women older than 40 years of age. Endocrine, 2015, 48(2):603-614. 

Group members

Group leader

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Other staff

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联系方式: 52362132(2132)、52362131(2131)


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